Biosystems
ProTReND is an online database of transcriptional regulatory networks. Transcriptional regulatory networks (TRN)s can bethought of as a group of transcription factors (regulatory proteins) which may activate and/or repress certain gene’s expression.
Obtaining and processing regulatory information is an important step towards the reconstruction of novel transcriptional regulatory networks. Furthermore, gathering bacterial TRNs, is not only important for reconstructing TRNs of model microorganisms such as Escherichia coli and Bacillus subtilis, but also for poorly described microorganisms.
ProTReND is aimed to bridge the gap between organism-specific and non-organism-specific databases by comprising regulatory data from several generic databases and other scientific papers that have described organism-specific bacterial TRNs
ProTReND provides relevant data regarding over 1500 regulators controlling over 46000 gene’s expression levels across 510 organisms. In addition, the database has data for over 62000 binding sites, allowing the discovery of new regulator-binding site-gene interactions, through the combination of standardized data from multiple sources. The sheer volume and interconnectivity of data make ProTReND a state-of-the-art database for bacterial transcriptional regulatory networks.